Just out of curiosity: Do you know of a working pen and paper adaptation of Bioware's Mass Effect franchise? I think there's no such official publication (though there might be one in the works, who knows), but there may be a good unofficial version.
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Probably most complete are these two d6-based Mass Effect RPGs. And there's a Cortex stab at one here (you have to register to see and download the files attached to the thread). Then there's Dagda who has been noodling away on a Mass Effect 2 RPG on his blog, I don't think it's downloadable but he says he's running it at cons. There's about a dozen less baked mods out there too.
Update - Wesley Schneider of Paizo has been running Mass Effect in Pathfinder and he has just published all his notes and stuff as Project Lobotomy.
There are few suggestions on converting Mass Effect into systems like Traveler, Fate or Savage World.
Otherwise there are no official Mass Effect RPGs.
I just ran across Mass Effect d6: The Unofficial RPG.
I myself am currently working on a Mass Effect Campaign Guide and Players Guide for Dungeons and Dragons 4th Edition. The sneak peaks are available at Mass Effect RPG.
I'm working on a Mass-Effect RPG currently in a d10 format. Though its not as common as a format as d20, I feel there is a better balancing between tech, biotics and normal combat.
Here's our Facebook page: Mass Effect RPG