Hot answers tagged holy-symbol
No, A character does not need to hold a Holy Symbol in his or her hands to benefit from it in any way. From the Rules Compendium pg274 Unlike other implements, a holy symbol can be used whether it is worn or held. If a creature wears or holds more than one holy symbol, none of these symbols function until only one remains (this rule is usually ...
It applies to all enemies. When you attack an enemy with an implement attack using a holy symbol, your enemies cannot gain combat advantage against you until the start of your next turn, "An enemy" followed by "your enemies". It seems pretty clear to me that it is intended for one attack to grant you protection against all.
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