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If you only want to use the OGL part of their rules, the answer is yes. See this previous question on Is it possible to use rules from OGL or GSL games in a computer game? You have to understand that license and adhere to its terms however. One drawback is that you may not say "Pathfinder" or otherwise claim Pathfinder compatibility if purely using the OGL. ...

It depends on the system, since the creators' attitudes vary so much. Most companies are not eager to give out these licenses as that makes you competition for their products, but there are enough exceptions to make licensing a system a reasonable route to go. As a rule, you will need some kind of written agreement to license a system. For GURPS ...

Mongoose Traveller actually has a pretty rich set of open licensing. The Mongoose Traveller rules are OGL You can actually do not-for-profit stuff based off earlier Traveller releases You can license use of the Traveller license with some restrictions You can even use a specific Traveller sector, the "Foreven Free Sector." ...

There is not an official RPG setting for The Sword of Truth. Terry Goodkind will not license the book for an RPG. From the official Sword of Truth FAQ: QUESTION 4 Are there any SOT RPGs or video games or D&D type games out there? ANSWER 4 No, there is not. Terry is adamantly against having his books made into a video game because he sees ...

As someone mentioned in the comments the Pathfinder MMO rights are already claimed by a subsidiary of Pazio. For more on their licensing I'd check here. Info on the OGL can be found here. I'd highly advise contacting Paizo as I am sure they will be happy to let you know what you can and cannot do with their information. See the first link for more info.