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If you can play with no hands, you should be able to play with one hand.
Pan flutes vary in size, as a simple Google image search reveals. Depending on the style, it might require one or two hands. A simple 4 or 5 pipe flute is certainly designed for single hand use, while a 20 pipe flute may not be reasonable to use in a single hand. In extreme circumstances, you might even argue it occupies a shield slot.
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