I think that the answer you are looking for is actually a lot simpler then most of the ones already posted here. My personal method when dealing with a large variety of rooms/etc where there is no value in the majority of the rooms is to simply skip the hide and seek game-play quickly. Here is a scenario...

DM: You enter the 3rd kitchen on the 5th floor. *brief description of room*
DM: Any searching of this room yields nothing useful.
Players: Alright, we will move to the next room.

OR

Player: I search the room for treasure.
DM: You find nothing of value.

This handles the situation quickly and efficiently. If there is something worthwhile in the room, the first thing most groups will do is search for it. By putting the information in front of them like this, you stop them having to wonder about what could be hidden. Obviously I don't mention this in rooms with any sort of crucial information and let players search via rolls/etc.

Also, specifically to D&D 5th edition, you have passive perception. I inherently use this for most rooms unless the party specifically asks to search it. Generally most things are not elaborately hidden so they are easy to stumble across.

I think that the answer you are looking for is actually a lot simpler then most of the ones already posted here. My personal method when dealing with a large variety of rooms/etc where there is no value in the majority of the rooms is to simply skip the hide and seek game-play quickly. Here is a scenario...

DM: You enter the 3rd kitchen on the 5th floor. brief description of room
DM: Any searching of this room yields nothing useful.
Players: Alright, we will move to the next room.

or

Player: I search the room for treasure.
DM: You find nothing of value.

This handles the situation quickly and efficiently. If there is something worthwhile in the room, the first thing most groups will do is search for it. By putting the information in front of them like this, you stop them having to wonder about what could be hidden. Obviously I don't mention this in rooms with any sort of crucial information and let players search via rolls/etc.

Also, specifically to D&D 5th edition, you have passive perception. I inherently use this for most rooms unless the party specifically asks to search it. Generally most things are not elaborately hidden so they are easy to stumble across.