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Assuming that you can use a familiar as a safety-deposit box (because the DM's has ruled so), how would this interact with an magic item that makes an extra-dimensional space?
What happens if you give your familiar a Bag of Holding, Portable Hole, or similar item, and then you dismiss your familiar to its pocket dimension? In particular, such items when put in each other tend to burst and cause problems. Does that happen in this case as well? If not, why not?
Nothing.
The rules for the interaction between a Bag of Holding and a Portable Hole are specific to each other, and don't apply to any other type of planar travel. For example, there is no interaction between a Bag of Holding and a portal created by the Gate spell, or someone transported using Teleportation or Plane Shift.
Thus, there is no reason to think that a familiar's mode of transport would work any differently, so there is no interaction, by RAW.
