I have this multi-class warrior: Superstitious Barbarian, Guide Ranger, and Two-Handed Fighter.
Can I effectively combine Rage, Ranger’s Focus, and Overhand Chop into one fabulous attack?
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The Overhand Chop ability will apply on any single attack, and can definitely be used with any other effects in place.
If using Overhand Chop, you may also find the Vital Strike line of feats useful, as these will also apply on the single attack action, and further increase your damage.