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I've been playing a character in Pathfinder recently who is a divine spellcaster but does very little damage in combat, so I've been using a lot of debilitating spells (most notably Terrible Remorse) to stop enemies instead of fighting them head on, and letting party members deal with them.

The only issue is that neither my DM or I know the actual mechanics for determining Difficulty Classes, so we wind up doing a different thing each time. Is anyone familiar with the actual way it works?

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From The Pathfinder SRD page on the Cleric :

The Difficulty Class for a saving throw against a cleric’s spell is 10 + the spell level + the cleric’s Wisdom modifier.

The page on the Wizard has this :

The Difficulty Class for a saving throw against a wizard's spell is 10 + the spell level + the wizard's Intelligence modifier.

So the generic formula for any spellcaster class looks like 10 + Spell Level + The class' Relevant Attribute for Spells.

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    \$\begingroup\$ The feat 'Spell Focus (Enchantment)' will bump up the DC for Terrible Remorse a bit too ;) \$\endgroup\$ – Macona Feb 27 '12 at 9:25

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