Each poisoning event is a separate thing, so if you get poisoned repeatedly, you have to save against all of them independently, and each of them affects you independently.
- Yes, if you get hit with poisoned weapons repeatedly, you have to save each time it happens.
- No, there's no rule that makes you immune to further poisoning just because you have been poisoned or have saved against being poisoned.
- If you succeed on your Con save at the end of each turn to stop being paralyzed by carrion crawler mucus, it ends that specific instance of poisoning, but doesn't remove any other instances.
If you have been hit by multiple instances of the same poison, according to the "Combining Game Effects" note in the DMG Errata (and in future DMG printings at the end of the Combat section), only one instance of the poison actually affects you. Normally this doesn't matter because you can't become 'double-paralyzed' or something. The only time it really changes anything would probably be with the ongoing damage from Burnt Othur Fumes. If you got multiple Othur exposures, I think in that case you'd still save against each instance of the exposure at the start of each turn, but only the first save each turn would determine whether you take the poison damage or not.
So to give an example:
Suppose Geralt the Ranger is being pelted with poisoned arrows. We'll assume they use Crawler Mucus just to make this easier.
On turn 1, Geralt is hit by an arrow and fails his save. He becomes paralyzed. At the end of Geralt's turn, he rolls another save, and fails again. He's still paralyzed.
On turn 2, Geralt takes two more hits, and rolls two saves against those new poison instances. He succeeds on one and fails the other. He now has two instances of poison affecting him. At the end of his turn, Geralt rolls two Con saves. He succeeds one, but fails the other. He remains paralyzed, with only one poison instance still in play against him.
On turn 3, all the attacks miss, and Geralt makes one save at the end of his turn. He succeeds, and is finally un-paralyzed.
On turn 4, Geralt takes another two hits, fails his save against one, and becomes paralyzed again. Geralt's player yells at the DM and stomps out of the room in frustration.
In general, this makes sense for being 'more badly poisoned' by multiple exposures (i.e., it's reasonable that somebody who gets hit by seventeen poisoned darts is suffering more than somebody who only got hit by one).
However, this is enough of an edge case and has enough complication from the aforementioned errata that your DM might decide that while you're under a poison's effect, you can't be affected a second time by the same poison, and there is a reasonable argument for that method of handling this.