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Are there any magic items or spells that extend the natural life of a creature (meaning the age of the creature, and not preventing death from a wound or injury) or that grants immortality in the 5e books published by Wizards of the Coast.
I'm looking only for options available to PCs through character creation or options available to the DM via canon books.
What is not a valid answer is:
or similar effects.
(Heavily adapted from my answer here)
The easiest way to achieve effective immortality is to use spells. A wizard has access to several of them once they get higher level spell slots.
Sequester will allow the PC to put themselves into a state of suspended animation during which they will not age. This will allow them to span any amount of time without aging (though it will mean that they are out of action for that time).
Clone will provide the PC with fresh young bodies to use once their older body dies. With enough of these, they can last an infinite amount of time. See this Q&A for more discussion on this.
Wish obviously wish can do anything, including granting immortality. A wish for immortality is unlikely to be granted in a straightforward manner though and would be a good opportunity for the DM to implement some sort of curse or other downside on the PC as a result of their wish.
Imprisonment would work in any of its flavors since the targeted creature does not age while under its effects.
True polymorph can allow you to extend your life by changing into a creature with a longer lifespan than you. Some good potential options: devils are immortal (MM), hags are "virtually immortal", and ancient dragons are listed as living for "over a thousand years".
If your PC isn't a spellcaster you can always try to find them assistance from someone or something capable of casting the spells. For example, Djinni can cast wish as well as some magic items.
(Tomb of Annihilation spoilers)
The Ring of Winter listed in Tomb of Annihilation will prevent aging.
At 18th level, druids get the Timeless Body feature:
[T]he primal magic that you wield causes you to age more slowly. For every 10 years that pass, your body ages only 1 year.
Combine this with a long-lived race like the elf or warforged and you easily have thousands of years of life.
An Oath of Ancients paladin at level 15 gets:
Additionally, you suffer none of the drawbacks of old age, and you can’t be aged magically.
Which seems likely to be able to prevent death from old age as well if your DM interprets death from old age as a drawback.
Warlocks with the Undying Patron also have a similar ability. (thanks @Himitsu_no_Yami)
A DM can grant the Epic Boon of Immortality to give a PC immortality. This assumes that they have a 20th level PC.
Races like elves and warforged can live for an incredible amount of time (unknown even in the case of the warforged).
The maximum lifespan of the warforged remains a mystery; so far, warforged have shown no signs of deterioration due to age. (Wayfinder's Guide to Eberron)
Starting as one of these races can get you a good way towards immortality without anything else, and will enhance the effects of many of the options above.
State your wish to the GM as precisely as possible. The GM has great latitude in ruling what occurs in such an instance; the greater the wish, the greater the likelihood that something goes wrong.
"I wish to be immortal." would be the simplest way. A somewhat better way would be "I wish to cease aging (or be unable to die) until such time as I, of my own free will and under no duress, want this effect to end". That gives the DM fewer ways to monkey's paw your wish and gives you an out.
At 18th level you get the Timeless Body feature which states
Starting at 18th level, the primal magic that you wield causes you to age more slowly. For every 10 years that pass, your body ages only 1 year.
which effectively increases your lifespan by 10 times.
You get Timeless Body at 15th level but it's different than the Druid's. It states
At 15th level, your ki sustains you so that you suffer none of the frailty of old age, and you can’t be aged magically. You can still die of old age, however. In addition, you no longer need food or water."
while it doesn't explicitly grant immortality it might still help.
At level 15 you get the Undying Sentinel feature which states
Additionally, you suffer none of the drawbacks of old age, and you can’t be aged magically.
which is similar to the Monk's feature
This is the Undying Nature feature which states
In addition, you age at a slower rate. For every 10 years that pass, your body ages only 1 year, and you are immune to being magically aged."
Though it's a bit unpredictable and you may get older instead. On the Wild Magic table it says
35–36: Roll a d10. Your age changes by a number of years equal to the roll. If the roll is odd, you get younger (minimum 1 year old). If the roll is even, you get older."
The Ring of Winter has an effect called Frozen Time which states.
As long as you wear the ring, you don’t age naturally. This effect is similar to suspended animation, in that your age doesn’t catch up to you once the ring is removed.
There's also the Potion of Longevity. There's a bit of risk with this one if you drink it more than once and you'll never be able to drink it more than 9 times but here's what it says.
When you drink this potion, your physical age is reduced by 1d6 + 6 years, to a minimum of 13 years. Each time you subsequently drink a potion of longevity, there is a 10 percent cumulative chance that you instead age by 1d6 +6 years.
Boon of Immortality
You stop aging. You are immune to any effect that would age you, and you can’t die from old age.
of course this requires level 20 but it is an option.
Disclaimer: This was partly taken from Rubiksmoose's answer but I wanted to add details about how it could work.
The Clone spell would let you create a new body for yourself and, as seen here, would allow you to resurrect yourself into your clone body after dying of any means including old age. By default you need to be a Wizard with access to 8th level spells to do it and even then, it's extremely costly as you need a diamond worth at least 1,000 gold pieces as well as a chunk of your flesh. You also would need a vessel worth at least 2,000 gold pieces that has a sealable lid and is large enough to hold a Medium creature such as, for example, an expensive coffin. There's also the fact that it must remain undisturbed for the whole time until you die. There are a few potential methods you could use to get around parts of this.
Mostly taken from my answer there
This spell will not extend your body's life, but it does extend your soul's.
Casting Magic Jar allows your soul to leave your body without dying (and steal other people's bodies) Your soul survives even if your original body dies.
If the possessed body dies near the container, you get a saving throw to not die. If the container is destroyed and you aren't close to your original body (or it died), you die.
This means that when your body starts failing due to age, you can cast Magic Jar to take possession of a younger one, wnd when that one becomes too old, just rinse and repeat. The catch is that you also have to make sure your magic jar is well protected, as you can die if it is destroyed and your original body is gone.
Don't think anyone has mentioned moon druids yet. At level 10, a druid can shapeshift into an elemental. Although it would be up to the discretion of the DM, many would agree that elementals do not age in the same way as mortals. As elementals are immune to exhaustion, they don't need to sleep. You could happily take a short rest every so often and remain in elemental form indefinitely, never ageing.
Edit for quotes:
Wildshape guide for druids: https://www.dndbeyond.com/posts/635-druid-101-wild-shape-guide
Air elemental with condition immunities: https://www.dndbeyond.com/monsters/air-elemental
Druids resting while in wildshape: Can a Druid take a short rest while in wildshape form?
