My question isn't whether lycanthropy can be cured by Remove Curse. This question How can lycanthropy be cured? has already answered that. I'm wondering about the logistics of what would happen if a player decided to use the spell against an enemy lycanthrope.
In the spell text, there doesn't seem to be a save for unwilling creatures:
At your touch, all curses affecting one creature or object end. If the object is a cursed magic item, its curse remains, but the spell breaks its owner's attunement to the object so it can be removed or discarded. - PHB p271
I know it is contingent on the lycanthrope not being born with the curse, so the DM could always say that is the case, but that seems a bit too harsh to say this every time, and the DM could have set up a situation where it is already known when the lycanthrope was afflicted.
If, assuming the DM said yes it works, the spell was successfully used to cure the lycanthropy, what would happen to the creature's statblock? Obviously it would lose the features like the ability to shapechange, natural weapons, immunities and so on. But would it retain its ability scores? Its hitpoint pool? Anything else I haven't mentioned?