I would love to just say "yes", but actually it depends on the player and style of play. If you have a player who is good at coming up with details themselves, and you play the game in a very "ask questions" kind of way, and you're good at roleplaying NPCs as self-determined entities, then yes, you can have some awesome games. There are a couple caveats, however:
Don't advance too many Fronts at once. One player can only deal with so much stuff at one time.
Give them Hx with NPCs. This is an optional rule that lets you play the significant people in the PC's life, complete with helping/hindering. Play those NPCs with great seriousness and depth of character. If the PC develops a strong relationship with one of these NPCs, don't look at that NPC through crosshairs (at least not for a while). Then you can set up PC-NPC-GMPC triangles that work almost as well as PC-NPC-PC ones.
Give them access to medical attention. If the PC doesn't have any means of healing themselves, sooner or later (probably sooner) they're going to need to have recourse to an Angel or someone with a custom medical move, either in town, or traveling around the area, etc.
Let them play more than one character. This is just an option but it's worth mentioning. Some of the coolest movie "heroes" are duos.
In your note you also asked about "the pros and cons of co-MCing". Again, this depends on the two people involved, and the way you relate to each other creatively. The game is not really about having "secret plans" anyway, so if you're good at maintaining the wall between what you know and what your character knows, that's not a problem. The only special "rule" might be something like this: The MC promises not to view GMPCs through crosshairs, and instead just treats them like other PCs. If you do it right, playing a GMPC is just like playing a character: You think about that character's drives and concerns, and then you just do whatever they would do.
Remember: Both the MC and the PCs are setting up dramatic situations involving personal interaction in a world of limited resources and then playing to see what happens. They're not playing simply to antagonize each other. So if you're both dedicated to seeing that vision play out, co-MCing will not be a problem for you. It will be a lot like co-writing a movie.