In Vampire: The Requiem you use the lower of your Dexterity or Wits to determine your base defense. Is there is a merit/power/devotion/etc. that allows you to use the higher of the two instead?
Fighting Style: Boxing (World of Darkness, page 110)
Duck and Weave (••): Your character is trained to instinctively duck and evade an opponent’s blows. Use the higher of your character’s Dexterity or Wits to determine his Defense when dealing with Brawl-based attacks only (not against Weaponry attacks). If a combination of Brawl- and Weaponry-based attacks is focused on your character in the same turn, use his normal Defense against both.
In World of Darkness: Slasher, a book often paired with Hunter: the Vigil and designed for creating characters in the mold of movie antagonists like Jason Voorhees, Freddy Krueger, Hannibal Lecter, or the like, there's the Atavism merit (p.127):
Prerequisite: Dexterity 3 or Wits 3, Intelligence 2 or below.
Like an animal, you use the higher of your Dexterity and Wits to determine your Defense. You suffer a -2 modifier on non-confrontational Social rolls. If you raise your Intelligence above 2 then you no longer benefit from this Merit.
It's at character creation only, and I believe restricted to this unusual template.