The Imbued (the protagonists of Hunter: the Reckoning) are universally empowered by an otherworldly source to accomplish literally miraculous deeds. They have the ability to pierce supernatural protections and disguises and hear what could be described as the Voice of God guiding them. The themes of HtR are about heroism, fanaticism, truth, and faith, as well as being explicitly a "new" faction in the classic World of Darkness who have arrived at the cusp of the End of Days. The Imbued divide themselves by Creed, representative of their philosophical approach to how to treat monsters: Avengers, Martyrs, Defenders, Innocents, Judges, Redeemers, Visionaries, Hermits, and so on.
Hunters in Hunter: the Vigil may have supernatural power, and may have issues of heroism and faith, but they have no particular universal endorsement or capability. Their stories are about desperate last stands and the desire to defeat, destroy or exploit monsters. Vigil hunters divide themselves into Compacts and Conspiracies, which are as much social groupings as power sources.