Yes, this is possible. All old WoD games are based of the same ruleset.
Using multiple books is somewhat of a challenge because normally, all factions dislike and/or hate each other. The power level also varies. Maybe power level is not the correct word, I'd say the "squishyness". You cannot assume one books character will withstand as much punishment as the next. However, if you let the players sort it out, it works quite well. They know what they can and can not do.
The only special thing about Wraith is that all other characters can interact without thinking about it or spending points. A wraith can not. You need to spend points to talk with your party and maybe you want to spend points to interact with the environment (although depending on your group it might not be necessary).
You may not actually get a storyline based on your book. With many different books on the table, that might not be possible. Our starting storyline for example went like this:
The paramedic (mage) was called to a crime scene to see if he could help the victim. He could not. It was sucked dry. However, he noticed that the soul was still there, unable to completely leave the material world behind yet (wraith). As the police found out, the serial killer was a crazy lunatic and talked of himself as "the vampire". That brought up the cities real vampires, because the last thing they wanted was police and press asking around for suspicious vampire-like activity. I don't remember how the Garou go into the party, I think the killer stalked his sister or something.
Anyway, in the end it was neither party members "by the book" nemesis, it was a completely different story altogether. In my mind, that's the strength of WoD: the option to combine all books into a greater story.
Just don't forget you need to communicate with your party members. As a wraith, that's not the default.