The snarky answer is: "whatever way your DM wants to interpret it".
The short answer is that yes, the way I read it, you should get Forseen Hit's bonus against all four creatures. (But again, I see a case for the other interpretation also)
The trigger for this power is not "you make an attack roll against an enemy", but "you use an attack power".
There is no reason to infer a target line other than that of the At-Will or Basic Attack power Forseen Hit is piggybacking off of. While it's clear that the choice of wording is unideal (hence the varying interpretations observed even within these two conflicting answers), I don't think the intent was to unintentionally exclude multi-target powers in the first place.
For point of comparison, consider the Wizard's "Orb of Deception" power. The trigger is "an enemy", and has verbage to support the scenario where the power has more than one target. Specifically, this clause:
"Choose another enemy within 3 squares of the target. The chosen
enemy cannot also be a target of the original attack."
The second clause only is at issue when the power has multiple targets to begin with, and the trigger: "miss an enemy" doesn't care how many targets the power had in the first place.
Likewise, for Foreseen Hit, the trigger is conclusive:
"when you use an at-will power"
Foreseen Hit doesn't care if you're using Thunderwave or Magic Missile, just that you're using an at-will attack. "an enemy" is irrelevant, because the effect modifies:
"the triggering attack"
and not "the triggering attack roll" (which would imply a maximal target of one).
In any case, "the enemy's" is ambiguous in regards to plurality, so that also cannot be used to determine target.
In short, this is what I consider the series of events that happen when you use this power to be:
- You make an attack targeting at least one enemy.
- You trigger "Foreseen Hit".
- "Foreseen Hit" modifies your attack power.
- You make attack rolls against every target, as normal.
- You resolve the hit by comparing the result against each target's lowest defense, as per Foreseen Hit.
- If a target is hit, apply Foreseen Hit's bonus damage and condition.