These days as a GM I use 1PG Broadsword for cheezy 80s style Sword and Sorcery, Toon for Warner Bros style cartoon setting, Six Gun for my western setting, Cartoon Action Hour for a variety of settings that are all in the style of 80s saturday morning cartoons, Slasher Flick for cheezy 80s horror, and Homebrew FASERIP for Marvel, Star Wars, Call of Cthulhu, Robotech, D&D, and anything else. I also play Pathfinder and Macabre Tales, but only as a player... not a GM.
I've been running the same campaign every Sunday at 2pm since 1984.