A creative player might use Mage Hand to duplicate the effects of True Strike if he is into it. For instance, you can use this cantrip to untie the enemy's belt or lower his pants.
Beside morale effects that might well enough give you advantage on your next turn, but you cannot count on those agains undeads, for instance, have you ever tried to move with your pants down?
You will most likely fall prone, so, you can argue that the enemy speed is now zero. Also, have you tried to resist being pulled while your pants are down? Yeah, you would most likely fall prone, so not a long shot to give disavantage in resisting that kind of maneuver (I would even consider auto-success)
Besides, in order to pull your pants up, you will need at least a free hand (if they need a belt to remain in place, two hands and one full turn worth of actions).
So, if the enemy is using a shield, he will have to drop his weapon in order to dress up.
Pulling this off will call for a Sleight of Hand check.
And, if you also have Vicious Mockery, you can crack dick jokes that will actually hurt the enemy for a few d4 and keep him disadvantaged. A Valor Bard or an Eldritch Knight can pull this off without failing to pummel said enemy.
Expect all foes to be wearing togas or plate armor afterwards.
EDIT: If the DM goes for togas, you can instead pull the toga over the enemy's head for a free blinded effect. That is better then Darknes/Devil's Sight trick because it do not hinder your allies and uses only a cantrip slot.