Experienced Keepers
The rules for play and for character creation are present in the Keeper's Guide, and it appears to be meant to be a stand-alone book for a Keeper who is already familiar with the game, and its common setting of the 1920s. If a Keeper were shifting to this edition from an earlier one, the Keeper's Guide would be sufficient.
New Keepers
Those new Keepers without a grounding in the game, its inspirational material, its setting and conceits, and/or who wish to be in tune with the advice given to new players and with the point of view fostered for play will need to consider getting, or having access to, both.
Players
Likewise, players will find all the information they need to create and ground characters in the 1920s setting if they obtain the Investigator's Handbook and will require nothing from the Keeper's Guide. If they later intend to run the game as well as play it, however, they will need both.
Quickstart
It should be noted that the system rules are available in a PDF Quickstart format from the usual sources as well as Chaosium, so they can be investigated prior to making a purchase.
The Table of Contents for the Keeper's Guide
Introduction
HP Lovecraft and the Cthulhu Mythos
- Creating Investigators
- Skills
- Game System
- Combat
- Chases
- Sanity
- Magic
- Playing the Game
- Tomes of Eldritch Lore
- Grimoire
- Artifacts and Alien Devices
- Monsters, Beasts, and Alien Gods
- Scenarios (2)
- Appendices
421 pages of content
The Table of Contents for the Investigator's Handbook
- Introduction
- The Dunwich Horror
- Creating Investigators
- Occupations
- Skills
- Investigator Organizations
- Life as an Investigator
- The Roaring Twenties
- Advice for Players
10 Reference
- Character Sheets
268 pages of content