There Are No Mechanical Drawbacks
I've played a lycanthrope1 in Pathfinder and were it not for the fact that the campaign was lycanthrope-unfriendly2, my half-orc werewolf inquisitor3 would've totally stayed in hybrid form all the time.
So what if the bad guys know that silver overcomes your damage reduction? You still have damage reduction, and most of the monsters aren't eating you with silver teeth.
One thing, though. A natural lycanthrope (in other words, the best kind) can inflict the curse of lycanthropy with its bite attack; the DM may rule that when a creature you kill whom you've bitten is the subject of the spell raise dead et. al. that the creature is brought back from the dead as an afflicted lycanthrope if the creature qualifies and fails its saving throw. (According to raise dead, "curses are not undone" by being brought back from the dead.)
- Unintentionally. My character got bit and failed the saving throw.
- The campaign was set in Magic: The Gathering's Innistrad but used Pathfinder rules.
- He was as cool as he sounds.